分子生物学试剂

【现货FTI-277- CAS 170006-73-2-小分子价格优惠】

FTI 277是一种抑制法呢基转移酶(FTase)的抑制剂(IC50 = 0.5 nM)。抑制全细胞的 H-Ras 和 K-Ras 加工(IC50值分别为0.1和10 nM),破坏mapk的组成型H-Ras特异性激活。在人恶性胶质瘤细胞和许多其他肿瘤细胞系中引起显著的抗增殖作用。FTI-277是法尼基转移酶FTase抑制剂,高效Ras CAAX肽模拟物,可抑制H-Ras和K-Ras信号转导。所有产

  • 进口/国产: FTI 277 Chemical Structure CAS NO. 170006-73-2
  • 产地/品牌: FTI 277 Chemical Structure CAS NO. 170006-73-2
  • 型号/货号: FTI 277 Chemical Structure CAS NO. 170006-73-2小分子抑制剂
  • 报价/价格: FTI 277 Chemical Structure CAS NO. 170006-73-2价格优惠
  • 供应商: 北京微宣科技有限公司
  • 规格/数量: FTI 277 Chemical Structure CAS NO. 170006-73-2小分子抑制剂现货供应

FTI 277是一种抑制法呢基转移酶(FTase)的抑制剂(IC50 = 0.5 nM)。抑制全细胞的 H-Ras 和 K-Ras 加工(IC50值分别为0.1和10 nM),破坏mapk的组成型H-Ras特异性激活。在人恶性胶质瘤细胞和许多其他肿瘤细胞系中引起显著的抗增殖作用。

FTI-277是法尼基转移酶FTase抑制剂,高效Ras CAAX肽模拟物,可抑制H-Ras和K-Ras信号转导。

所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务


Description

FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. IC50 value: Target: FTase inhibitor in vitro: Treatment with FTI-277 (20 microM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types [1]. Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner [3]. in vivo: FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice [2].

Molecular Weight

447.61

Formula

C₂₂H₂₉N₃O₃S₂

CAS No.

170006-73-2

SMILES

CSCC[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • [1]. Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152(4):404-11.

    [2]. Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633.

    [3]. Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34(8):815-26.


首页
仪器
试剂
联系