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【原装现货Anti-TREM2 antibody抗体ab86491价格优惠】

abcam Anti-TREM2 antibody抗体ab86491 OverviewProduct nameAnti-TREM2 antibody [RM0139-5J46]See all TREM2 primary antibodiesDescriptionRat monoclonal [RM0139-5J46] to TREM2Host speciesRatSpecies reactivit

  • 进口/国产: abcam Anti-TREM2 antibody抗体ab86491
  • 产地/品牌: Anti-TREM2 antibody抗体ab86491
  • 型号/货号: abcam Anti-TREM2 antibody抗体ab86491
  • 报价/价格: abcam Anti-TREM2 antibody抗体ab86491价格优惠
  • 供应商: 北京微宣科技有限公司
  • 规格/数量: 原装abcam Anti-TREM2 antibody抗体ab86491现货供应

abcam Anti-TREM2 antibody抗体ab86491 Overview

  • Product name

    Anti-TREM2 antibody [RM0139-5J46]
    See all TREM2 primary antibodies

  • Description

    Rat monoclonal [RM0139-5J46] to TREM2

  • Host species

    Rat

  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Human大小鼠步态实时检测分析处理系统,转棒疲劳仪,kds微量注射泵,炎症疼痛模型自动检测仪,穿梭分析系统,社会交往实验分析系统,条件性恐惧实验,立体定位仪,动物代谢分析,morris水迷宫实验原理morris水迷宫实验视频分析系统,动物实验平台跑步机,强迫游泳,震惊反射实验分析系统,动物行为学实验

  • Immunogen

    Mouse recombinant protein of the extracellular EC-domain of TREM2

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

  • Storage buffer

    Constituent: PBS

  • Concentration


    Find concentration of your lot

    • 100 µg at 0.5 mg/ml

  • Purity

    Protein A purified

  • Purification notes

    The IgG fraction of culture supernatant was purified by Protein A affinity chromatography.

  • Clonality

    Monoclonal

  • Clone number

    RM0139-5J46

  • Isotype

    IgG2b

  • Research areas

    • Immunology

    •  

    • Innate Immunity

    •  

    • Macrophage / Inflamm.

Associated products

  • Compatible Secondaries

    • Goat Anti-Rat IgG H&L (Alexa Fluor® 488) (ab150157)

    • Goat Anti-Rat IgG H&L (HRP) (ab205720)

  • Isotype control

    • Rat IgG2b, kappa monoclonal [RTK4530] - Isotype control (ab18541)

  • Recombinant Protein

    • Recombinant Human TREM2 protein (ab153366)

Target

  • Function

    May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

  • Tissue specificity

    Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.

  • Involvement in disease

    Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.

  • Sequence similarities

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.


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